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Effectiveness of proton pump inhibitor in unexplained chronic cough

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  • Hye Jung Park
  • Yoo Mi Park
  • Jie-Hyun Kim
  • Hye Sun Lee
  • Hyung Jung Kim
  • Chul Min Ahn
  • Min Kwang Byun

Abstract

Background: Current guidelines recommend that patients with unexplained chronic cough undergo empirical proton pump inhibitor (PPI) treatment, but scientific evidence for this treatment is lacking. We investigated the effectiveness and appropriate dose of PPI therapy in chronic cough. Methods: We included 27 patients with unexplained chronic cough after excluding subjects with positive response to postnasal drip medication. Subjects were randomized to a placebo, standard, and high dose of PPI groups with blinding. The drug or placebo was administered orally for 8 weeks, and the Leicester Cough Questionnaire (LCQ) score and visual analogue scale (VAS) scores were collected. Results: The LCQ score in the PPI group significantly improved from 0 weeks (11.4 ± 1.4) to 4 weeks (14.8 ± 1.4) and to 8 weeks (17.1 ± 1.4), whereas that in the placebo group did not improve from 0 weeks (13.7 ± 1.1) to 8 weeks (11.8 ± 1.4); the difference between the 2 groups was significant (P

Suggested Citation

  • Hye Jung Park & Yoo Mi Park & Jie-Hyun Kim & Hye Sun Lee & Hyung Jung Kim & Chul Min Ahn & Min Kwang Byun, 2017. "Effectiveness of proton pump inhibitor in unexplained chronic cough," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0185397
    DOI: 10.1371/journal.pone.0185397
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