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The significant effects of cerebral microbleeds on cognitive dysfunction: An updated meta-analysis

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  • Xuanting Li
  • Junliang Yuan
  • Lei Yang
  • Wei Qin
  • Shuna Yang
  • Yue Li
  • Huimin Fan
  • Wenli Hu

Abstract

Objective: Accumulated data suggests that cerebral microbleeds (CMBs) play an important role in the decline of cognitive function, but the results remain inconsistent. In the current study, we aimed to investigate the association between CMBs and cognitive function, as well as the various effects of CMBs on different domains of cognition. Methods: We searched through the databases of PubMed, Embase, Cochrane Library, and ScienceDirect. After a consistency test, the publication bias was evaluated and a sensitivity analysis was performed with combined odds ratios (OR) and standardized mean difference (SMD) of CMBs. Results: A meta-analysis of 25 studies with 9343 participants total was conducted. Patients with CMBs had higher incidence of cognitive impairment (OR:3.5410; 95% confidence interval [CI] [2.2979, 5.4567], p

Suggested Citation

  • Xuanting Li & Junliang Yuan & Lei Yang & Wei Qin & Shuna Yang & Yue Li & Huimin Fan & Wenli Hu, 2017. "The significant effects of cerebral microbleeds on cognitive dysfunction: An updated meta-analysis," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0185145
    DOI: 10.1371/journal.pone.0185145
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