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U-shaped relationship between serum phosphate and cardiovascular risk: A retrospective cohort study

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  • Nicholas Hayward
  • Andrew McGovern
  • Simon de Lusignan
  • Nicholas Cole
  • William Hinton
  • Simon Jones

Abstract

Background: High serum phosphate is associated with coronary artery disease in patients with normal and impaired renal function. We asked: Does the serum phosphate range provide prediction of primary cardiac events? We extracted coded primary care data for over 100,000 patients from a database of 135 primary medical practices. Patients aged between 18 and 90 years without pre-existing cardiovascular diagnoses were included from a potential sample of over 1·2 million individuals. Methods and findings: Binary logistic regression models were used to evaluate the contribution of QRISK factors and electrolytes, including serum phosphate, to cardiac outcomes at five and nine years following an initial phosphate measurement. At five-year review (n = 113,993), low serum phosphate (OR 1·75, 95%CI 1·36–2·23, p

Suggested Citation

  • Nicholas Hayward & Andrew McGovern & Simon de Lusignan & Nicholas Cole & William Hinton & Simon Jones, 2017. "U-shaped relationship between serum phosphate and cardiovascular risk: A retrospective cohort study," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0184774
    DOI: 10.1371/journal.pone.0184774
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