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Immune response to hepatitis B vaccination in HIV-positive individuals with isolated antibodies against hepatitis B core antigen: Results of a prospective Italian study

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Listed:
  • Giulia Morsica
  • Sabrina Bagaglio
  • Vincenzo Spagnuolo
  • Antonella Castagna
  • Clelia Di Serio
  • Andrea Galli
  • Liviana Della Torre
  • Andrea Andolina
  • Alexander Pramov
  • Caterina Uberti-Foppa

Abstract

Background and aim: Antibodies against hepatitis B core antigen (anti-HBc) are found in 14–44% of patients with HIV infection, but it is still unclear whether hepatitis B virus (HBV) vaccination should be recommended for HIV-positive subjects with isolated anti-HBc (IAHBc). We examined the rate of anamnestic and primary responses (ARs and PRs) and associated factors in a group of HIV-infected patients with an IAHBc profile. Methods: This prospective study recruited 25 HIV-positive patients with anti-HBc alone who were vaccinated against HBV infection. Those without an AR (anti-hepatitis B envelope antigen [anti-HBs] levels of 10 but

Suggested Citation

  • Giulia Morsica & Sabrina Bagaglio & Vincenzo Spagnuolo & Antonella Castagna & Clelia Di Serio & Andrea Galli & Liviana Della Torre & Andrea Andolina & Alexander Pramov & Caterina Uberti-Foppa, 2017. "Immune response to hepatitis B vaccination in HIV-positive individuals with isolated antibodies against hepatitis B core antigen: Results of a prospective Italian study," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-10, September.
    • Handle: RePEc:plo:pone00:0184128
    DOI: 10.1371/journal.pone.0184128
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