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Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort

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  • Shou-Chien Hsu
  • Shy-Shin Chang
  • Meng-tse Gabriel Lee
  • Si-Huei Lee
  • Yi-Wen Tsai
  • Shen-Che Lin
  • Szu-Ta Chen
  • Yi-Chieh Weng
  • Lorenzo Porta
  • Jiunn-Yih Wu
  • Chien-Chang Lee

Abstract

Background: Fluoroquinolone is a commonly prescribed antimicrobial agent, and up to 20% of its users registers adverse gastroenterological symptoms. We aimed to evaluate the association between use of fluoroquinolone and gastrointestinal tract perforation. Methods: We conducted a nested case-control study on a national health insurance claims database between 1998 and 2011. The use of fluoroquinolones was classified into current (

Suggested Citation

  • Shou-Chien Hsu & Shy-Shin Chang & Meng-tse Gabriel Lee & Si-Huei Lee & Yi-Wen Tsai & Shen-Che Lin & Szu-Ta Chen & Yi-Chieh Weng & Lorenzo Porta & Jiunn-Yih Wu & Chien-Chang Lee, 2017. "Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0183813
    DOI: 10.1371/journal.pone.0183813
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