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Treatment continuation of four long-acting antipsychotic medications in the Netherlands and Belgium: A retrospective database study

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  • Flore Decuypere
  • Jan Sermon
  • Paul Geerts
  • Tom R Denee
  • Cedric De Vos
  • Bart Malfait
  • Mark Lamotte
  • Cornelis L Mulder

Abstract

Achieving greater continuation of treatment is a key element to improve treatment outcomes in schizophrenia patients. However, reported treatment continuation can differ markedly depending on the study design. In a retrospective setting, treatment continuation remains overall poor among patients using antipsychotics. This study aimed to document the difference in treatment continuation between four long-acting injectable antipsychotics based on the QuintilesIMS LRx databases, national, longitudinal, panel based prescription databases of retail pharmacies, in the Netherlands and Belgium. Paliperidone palmitate once monthly, risperidone microspheres, haloperidol decanoate, and olanzapine pamoate were studied. This study demonstrated significantly higher treatment continuation of paliperidone palmitate once monthly compared to risperidone microspheres (p-value

Suggested Citation

  • Flore Decuypere & Jan Sermon & Paul Geerts & Tom R Denee & Cedric De Vos & Bart Malfait & Mark Lamotte & Cornelis L Mulder, 2017. "Treatment continuation of four long-acting antipsychotic medications in the Netherlands and Belgium: A retrospective database study," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-19, June.
    • Handle: RePEc:plo:pone00:0179049
    DOI: 10.1371/journal.pone.0179049
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    1. Giovanni Ostuzzi & Maria Angela Mazzi & Samira Terlizzi & Federico Bertolini & Andrea Aguglia & Francesco Bartoli & Paola Bortolaso & Camilla Callegari & Mariarita Caroleo & Giuseppe Carrà & Mariangel, 2018. "Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-17, August.
    2. P Takács & P Czobor & L Fehér & J Gimesi-Országh & P Fadgyas-Freyler & M Bacskai & P Rakonczai & A Borsi & R Hegyi & T Németh & J Sermon & I Bitter, 2019. "Comparative effectiveness of second generation long-acting injectable antipsychotics based on nationwide database research in Hungary," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-14, June.

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