IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0178611.html
   My bibliography  Save this article

Cardiac glycosides use and the risk and mortality of cancer; systematic review and meta-analysis of observational studies

Author

Listed:
  • Mohamed Hosny Osman
  • Eman Farrag
  • Mai Selim
  • Mohamed Samy Osman
  • Arwa Hasanine
  • Azza Selim

Abstract

Background: Cardiac glycosides (CGs) including digitalis, digoxin and digitoxin are used in the treatment of congestive heart failure and atrial fibrillation. Methods: PubMed, Scopus, Cochrane library, Medline and Web of Knowledge were searched for identifying relevant studies. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects model. Results: We included 14 case-control studies and 15 cohort studies published between 1976 and 2016 including 13 cancer types. Twenty-four studies reported the association between CGs and cancer risk and six reported the association between CGs and mortality of cancer patients. Conclusion: The anti-tumor activity of CGs observed in pre-clinical studies requires high concentrations which can’t be normally tolerated in humans. However, the estrogen-like activity of CGs could be responsible for increasing the risk of certain types of tumors.

Suggested Citation

  • Mohamed Hosny Osman & Eman Farrag & Mai Selim & Mohamed Samy Osman & Arwa Hasanine & Azza Selim, 2017. "Cardiac glycosides use and the risk and mortality of cancer; systematic review and meta-analysis of observational studies," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-22, June.
    • Handle: RePEc:plo:pone00:0178611
    DOI: 10.1371/journal.pone.0178611
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178611
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0178611&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0178611?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0178611. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.