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The association between vacA or cagA status and eradication outcome of Helicobacter pylori infection: A meta-analysis

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  • Dan Wang
  • Qiuping Li
  • Yuehua Gong
  • Yuan Yuan

Abstract

Background: H. pylori virulence factors, especially vacA and cagA are important in gastroduodenal disease pathogenesis and affect cure rates. This meta-analysis aimed to clarify the association between vacA or cagA status and eradication outcome of H. pylori infection. Methods: A literature search was performed using electronic databases to identify studies. Twenty-six prospective studies were determined eligible. Meta-analytical techniques were conducted to calculate eradication rates and pooled relative ratios (RR). Results: The eradication rate was greater approximately 10% in vacA s1 compared with vacA s2 infected patients, and the pooled RR was 1.164 (95%CI: 1.040–1.303, P = 0.008). A significant association existed between vacA s1 and higher eradication rates in Europe (RR: 1.203, 95%CI: 1.003–1.442, P = 0.046) and Asia (RR: 1.187, 95%CI: 1.028–1.371, P = 0.020), in triple therapy patients (RR: 1.175, 95%CI: 1.012–1.365, P = 0.035). Eradication rates were similar for vacA m1 and m2 genotypes (RR: 0.981, 95%CI: 0.891–1.080, P = 0.690), whereas they were higher by approximately 8% in cagA-positive compared with cagA-negative infected patients, with a pooled RR of 1.094 (95%CI: 1.025–1.168, P = 0.007). A significant association existed between cagA-positive and increased eradication rates in Europe (RR: 1.138, 95%CI: 1.000–1.295, P = 0.049) and Asia (RR: 1.118, 95%CI: 1.051–1.190, P

Suggested Citation

  • Dan Wang & Qiuping Li & Yuehua Gong & Yuan Yuan, 2017. "The association between vacA or cagA status and eradication outcome of Helicobacter pylori infection: A meta-analysis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-19, May.
    • Handle: RePEc:plo:pone00:0177455
    DOI: 10.1371/journal.pone.0177455
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    1. Justyna Wasielica-Berger & Patryk Gugnacki & Maryla Mlynarczyk & Pawel Rogalski & Agnieszka Swidnicka-Siergiejko & Stefania Antonowicz & Michalina Krzyzak & Dominik Maslach & Andrzej Dabrowski & Jaros, 2022. "Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland," IJERPH, MDPI, vol. 19(11), pages 1-12, June.

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