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Prognostic impact of diabetes mellitus on hepatocellular carcinoma: Special emphasis from the BCLC perspective

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  • Yu-Wen Su
  • Po-Hong Liu
  • Chia-Yang Hsu
  • Yun-Hsuan Lee
  • Cheng-Yuan Hsia
  • Shu-Yein Ho
  • Ming-Chih Hou
  • Harn-Shen Chen
  • Teh-Ia Huo

Abstract

Background: Diabetes mellitus (DM) is associated with higher incidence and poorer prognosis of hepatocellular carcinoma (HCC). The influence of DM on patient survival in different HCC stages is not known. Methods: A prospective dataset of 3,182 HCC patients was collected between 2002 and 2014. Patients were divided into three groups according to BCLC stages (BCLC stage 0 and stage A, BCLC stage B, BCLC stage C and stage D). We compared the cumulative survival rate of diabetic and non-diabetic patients in different BCLC groups. The correlation between DM and overall survival was also analyzed by multivariate Cox regression model within each group. Results: DM is present in 25.2% of all patients. Diabetic patients had lower cumulative survival in BCLC stage 0 plus BCLC stage A group (log rank p

Suggested Citation

  • Yu-Wen Su & Po-Hong Liu & Chia-Yang Hsu & Yun-Hsuan Lee & Cheng-Yuan Hsia & Shu-Yein Ho & Ming-Chih Hou & Harn-Shen Chen & Teh-Ia Huo, 2017. "Prognostic impact of diabetes mellitus on hepatocellular carcinoma: Special emphasis from the BCLC perspective," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0174333
    DOI: 10.1371/journal.pone.0174333
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    1. Yan-Gang Wang & Peng Wang & Bin Wang & Zheng-Ju Fu & Wen-Juan Zhao & Sheng-Li Yan, 2014. "Diabetes Mellitus and Poorer Prognosis in Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
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