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Long-term efficacy of oral calcium polystyrene sulfonate for hyperkalemia in CKD patients

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  • Mi-Yeon Yu
  • Jee Hyun Yeo
  • Joon-Sung Park
  • Chang Hwa Lee
  • Gheun-Ho Kim

Abstract

Background: Calcium polystyrene sulfonate (CPS) has long been used to treat hyperkalemia in patients with chronic kidney disease (CKD). However, its efficacy and safety profile have not been systematically explored. We investigated the long-term efficacy of oral CPS for treating mild hyperkalemia on an outpatient basis. Methods: We performed a retrospective analysis of ambulatory CKD patients who were prescribed CPS for > 1 week because of elevated serum potassium levels > 5.0 mmol/L. Patients were divided into four groups according to the length of time that they took a fixed dosage of CPS (Group 1, 1 year). Response was defined as a decrease in the serum potassium level (> 0.3 mmol/L) after treatment with CPS. Results: We enrolled a total of 247 adult patients with a basal eGFR level of 30 ± 15 mL/min/1.73 m2. All patients took small doses of CPS (8.0 ± 3.6 g/d), and serum potassium decreased in a dose-dependent fashion. Serum potassium of all patients decreased significantly from 5.8 ± 0.3 mmol/L to 4.9 ± 0.7 mmol/L with CPS treatment (P

Suggested Citation

  • Mi-Yeon Yu & Jee Hyun Yeo & Joon-Sung Park & Chang Hwa Lee & Gheun-Ho Kim, 2017. "Long-term efficacy of oral calcium polystyrene sulfonate for hyperkalemia in CKD patients," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0173542
    DOI: 10.1371/journal.pone.0173542
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