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Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease

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  • Marcin Krawczyk
  • Simone Zimmermann
  • Georg Hess
  • Robert Holz
  • Marc Dauer
  • Jochen Raedle
  • Frank Lammert
  • Frank Grünhage

Abstract

Latest data suggest that placental growth factor (PLGF), growth differentiation factor-15 (GDF-15) and hepatic growth factor (HGF) are involved in hepatic fibrogenesis. Diagnostic performance of these markers for non-invasive liver fibrosis prediction was evaluated based on liver histology and stiffness. In total 834 patients were recruited. Receiver-operating-characteristics were used to define cut-offs for markers correlating to fibrosis stages. Odds-ratios were calculated for the presence/absence of fibrosis/cirrhosis and confirmed in the sub-group of patients phenotyped by elastography only. Logistic and uni- and multivariate regression analyses were used to test for association of markers with liver fibrosis stages and for independent prediction of liver histology and stiffness. Marker concentrations correlated significantly (P

Suggested Citation

  • Marcin Krawczyk & Simone Zimmermann & Georg Hess & Robert Holz & Marc Dauer & Jochen Raedle & Frank Lammert & Frank Grünhage, 2017. "Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver disease," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0173506
    DOI: 10.1371/journal.pone.0173506
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