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Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy

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  • Shen-Hao Lai
  • Sui-Ling Liao
  • Ming-Han Tsai
  • Man-Chin Hua
  • Chih-Yung Chiu
  • Kuo-Wei Yeh
  • Tsung-Chieh Yao
  • Jing-Long Huang

Abstract

Background: Perinatal vitamin D deficiency is associated with a higher risk of wheezing in childhood. However, the relationship between vitamin D levels and lung function in infancy has not been investigated. The aim of this study was to investigate the impact of perinatal vitamin D levels on respiratory function and disease outcome in infancy. Materials and methods: Full-term infants without any chronic diseases or major anomalies were enrolled in the Prediction of Allergies in Taiwanese Children cohort study. Maternal and cord blood were collected for determining the 25(OH)D level. Questionnaires were recorded at birth and 6 months of age. Infant lung function, including tidal breathing analysis, respiratory mechanics, and forced tidal expiration, was tested at 6 months of age. Results: A total of 122 mother—infant pairs were enrolled in this study, and 71 infants underwent lung function testing at 6 months of age. 25(OH)D levels in maternal and cord serum were highly correlated (r2 = 0.457, p

Suggested Citation

  • Shen-Hao Lai & Sui-Ling Liao & Ming-Han Tsai & Man-Chin Hua & Chih-Yung Chiu & Kuo-Wei Yeh & Tsung-Chieh Yao & Jing-Long Huang, 2017. "Low cord-serum 25-hydroxyvitamin D levels are associated with poor lung function performance and increased respiratory infection in infancy," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0173268
    DOI: 10.1371/journal.pone.0173268
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