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Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity

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  • Pamela S Hair
  • Laura A Sass
  • Turaj Vazifedan
  • Tushar A Shah
  • Neel K Krishna
  • Kenji M Cunnion

Abstract

In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, inflammation and tissue destruction. The complement system is a major mediator of inflammation for many diseases with the effectors C5a and C3a often playing important roles. We have previously shown in a small pilot study that CF sputum soluble fraction concentrations of C5a and C3a were associated with clinical measures of CF disease. Here we report a much larger study of 34 CF subjects providing 169 testable sputum samples allowing longitudinal evaluation comparing C5a and C3a with clinical markers. Levels of the strongly pro-inflammatory C5a correlated negatively with FEV1% predicted (P

Suggested Citation

  • Pamela S Hair & Laura A Sass & Turaj Vazifedan & Tushar A Shah & Neel K Krishna & Kenji M Cunnion, 2017. "Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0173257
    DOI: 10.1371/journal.pone.0173257
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