IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0169489.html
   My bibliography  Save this article

Healthcare Costs for Treating Relapsing Multiple Sclerosis and the Risk of Progression: A Retrospective Italian Cohort Study from 2001 to 2015

Author

Listed:
  • Marcello Moccia
  • Raffaele Palladino
  • Roberta Lanzillo
  • Antonio Carotenuto
  • Cinzia Valeria Russo
  • Maria Triassi
  • Vincenzo Brescia Morra

Abstract

Background: Disease modifying treatments (DMTs) are the main responsible for direct medical costs in multiple sclerosis (MS). The current investigation aims at evaluating possible associations between healthcare costs for treating relapsing remitting MS (RRMS) and disease evolution. Methods: The present cohort study retrospectively included 544 newly diagnosed RRMS patients, prospectively followed up for 10.1±3.3 years. Costs for DMT administration and management were calculated for each year of observation. Following clinical endpoints were recorded: time to first relapse, 1-point EDSS progression, reaching of EDSS 4.0, reaching of EDSS 6.0, and conversion to secondary progressive MS (SP). Covariates for statistical analyses were age, gender, disease duration and EDSS at diagnosis. Results: At time varying Cox regression models, 10% increase in annual healthcare costs was associated with 1.1% reduction in 1-point EDSS progression (HR = 0.897; p = 0.018), with 0.7% reduction in reaching EDSS 6.0 (HR = 0.925; p = 0.030), and with 1.0% reduction in SP conversion (HR = 0.902; p = 0.006). Conclusion: Higher healthcare costs for treating MS have been associated with a milder disease evolution after 10 years, with possible reduction of long-term non-medical direct and indirect costs.

Suggested Citation

  • Marcello Moccia & Raffaele Palladino & Roberta Lanzillo & Antonio Carotenuto & Cinzia Valeria Russo & Maria Triassi & Vincenzo Brescia Morra, 2017. "Healthcare Costs for Treating Relapsing Multiple Sclerosis and the Risk of Progression: A Retrospective Italian Cohort Study from 2001 to 2015," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0169489
    DOI: 10.1371/journal.pone.0169489
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169489
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0169489&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0169489?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Emer Fogarty & Cathal Walsh & Christopher McGuigan & Niall Tubridy & Michael Barry, 2014. "Direct and Indirect Economic Consequences of Multiple Sclerosis in Ireland," Applied Health Economics and Health Policy, Springer, vol. 12(6), pages 635-645, December.
    2. Damiano Paolicelli & Sergio Iannazzo & Laura Santoni & Antonio Iaffaldano & Valentina Di Lecce & Alessia Manni & Vito Lavolpe & Carla Tortorella & Mariangela D'Onghia & Vita Direnzo & Elisa Puma & Mar, 2016. "The Cost of Relapsing-Remitting Multiple Sclerosis Patients Who Develop Neutralizing Antibodies during Interferon Beta Therapy," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-10, July.
    3. Andrius Kavaliunas & Michael Wiberg & Petter Tinghög & Anna Glaser & Hanna Gyllensten & Kristina Alexanderson & Jan Hillert, 2015. "Earnings and Financial Compensation from Social Security Systems Correlate Strongly with Disability for Multiple Sclerosis Patients," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Marcello Moccia & Andrea Tajani & Rosa Acampora & Elisabetta Signoriello & Guido Corbisiero & Adriano Vercellone & Primo Sergianni & Francesca Pennino & Roberta Lanzillo & Raffaele Palladino & Antonio, 2019. "Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-12, September.
    2. Isabela Maia Diniz & Augusto Afonso Guerra Junior & Livia Lovato Pires de Lemos & Kathiaja M Souza & Brian Godman & Marion Bennie & Björn Wettermark & Francisco de Assis Acurcio & Juliana Alvares & El, 2018. "The long-term costs for treating multiple sclerosis in a 16-year retrospective cohort study in Brazil," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-14, June.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. B. Svendsen & N. Grytten & L. Bø & H. Aarseth & T. Smedal & K-M. Myhr, 2018. "The economic impact of multiple sclerosis to the patients and their families in Norway," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 19(9), pages 1243-1257, December.
    2. Andrius Kavaliunas & Ali Manouchehrinia & Virginija Danylaite Karrenbauer & Hanna Gyllensten & Anna Glaser & Kristina Alexanderson & Jan Hillert, 2017. "Income in Multiple Sclerosis Patients with Different Disease Phenotypes," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-10, January.
    3. Marcello Moccia & Andrea Tajani & Rosa Acampora & Elisabetta Signoriello & Guido Corbisiero & Adriano Vercellone & Primo Sergianni & Francesca Pennino & Roberta Lanzillo & Raffaele Palladino & Antonio, 2019. "Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery," PLOS ONE, Public Library of Science, vol. 14(9), pages 1-12, September.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0169489. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.