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Effect of Peripheral Electrical Stimulation (PES) on Nocturnal Blood Glucose in Type 2 Diabetes: A Randomized Crossover Pilot Study

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Listed:
  • Merav Catalogna
  • Keren Doenyas-Barak
  • Roi Sagi
  • Ramzia Abu-Hamad
  • Uri Nevo
  • Eshel Ben-Jacob
  • Shai Efrati

Abstract

Background: Regulation of hepatic glucose production has been a target for antidiabetic drug development, due to its major contribution to glucose homeostasis. Previous pre-clinical study demonstrated that peripheral electrical stimulation (PES) may stimulate glucose utilization and improve hepatic insulin sensitivity. The aim of the present study was to evaluate safety, tolerability, and the glucose-lowering effect of this approach in patients with type 2 diabetes (T2DM). Methods: Twelve patients with T2DM were recruited for an open label, interventional, randomized trial. Eleven patients underwent, in a crossover design, an active, and a no-intervention control periods, separated with a two-week washout phase. During the active period, the patients received a daily lower extremity PES treatment (1.33Hz/16Hz burst mode), for 14 days. Study endpoints included changes in glucose levels, number of hypoglycemic episodes, and other potential side effects. Endpoints were analyzed based on continuous glucose meter readings, and laboratory evaluation. Results: We found that during the active period, the most significant effect was on nocturnal glucose control (P

Suggested Citation

  • Merav Catalogna & Keren Doenyas-Barak & Roi Sagi & Ramzia Abu-Hamad & Uri Nevo & Eshel Ben-Jacob & Shai Efrati, 2016. "Effect of Peripheral Electrical Stimulation (PES) on Nocturnal Blood Glucose in Type 2 Diabetes: A Randomized Crossover Pilot Study," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0168805
    DOI: 10.1371/journal.pone.0168805
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