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Is Adjuvant Cellular Immunotherapy Essential after TACE-Predominant Minimally-Invasive Treatment for Hepatocellular Carcinoma? A Systematic Meta-Analysis of Studies Including 1774 Patients

Author

Listed:
  • Min Ding
  • Ying Wang
  • Jiachang Chi
  • Tao Wang
  • Xiaoyin Tang
  • Dan Cui
  • Qijun Qian
  • Bo Zhai

Abstract

Purpose: Cellular immunotherapy has appeared to be a promising modality for the treatment of malignant tumor. The objective of this study was to evaluate the efficacy of cellular immunotherapy combined with minimally invasive therapy. Methods: We searched PubMed, Web of Science and The Cochrane Library through March 2016 for relevant studies. Short-term efficacy (the disease control rate, the control rate of quality life and the AFP descent rate) and long-term efficacy (overall survival (OS) and progression-free survival (PFS) rate) were compared as the major outcome measures. The meta-analysis was performed using Review Manager 5.3. Results: A total of 1174 references in 3 databases were found of which 19 individual studies with 1774 HCC patients enrolled in this meta-analysis. Meta-analysis results showed that cellular immunotherapy combined with minimally-invasive treatment significantly improved the measures of short-term response (the disease control rate (OR = 5.91, P = 0.007), the control rate of quality lift (OR = 3.38, P = 0.003) and the AFP descent rate (OR = 4.48, P = 0.02)). Also higher 6-month PFS (OR = 2.78, P = 0.05), ≥12-month PFS (OR = 3.56, P

Suggested Citation

  • Min Ding & Ying Wang & Jiachang Chi & Tao Wang & Xiaoyin Tang & Dan Cui & Qijun Qian & Bo Zhai, 2016. "Is Adjuvant Cellular Immunotherapy Essential after TACE-Predominant Minimally-Invasive Treatment for Hepatocellular Carcinoma? A Systematic Meta-Analysis of Studies Including 1774 Patients," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0168798
    DOI: 10.1371/journal.pone.0168798
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    References listed on IDEAS

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    1. Feng Xie & Xinji Zhang & Hui Li & Tao Zheng & Feng Xu & Rongxi Shen & Long Yan & Jiamei Yang & Jia He, 2012. "Adoptive Immunotherapy in Postoperative Hepatocellular Carcinoma: A Systemic Review," PLOS ONE, Public Library of Science, vol. 7(8), pages 1-7, August.
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    Cited by:

    1. Han-Yue Mo & Ying-Yang Liao & Xue-Mei You & Alessandro Cucchetti & Bao-Hong Yuan & Ru-Hong Li & Jian-Hong Zhong & Le-Qun Li, 2017. "Timely meta-analysis on the efficacy of adoptive immunotherapy for hepatocellular carcinoma patients after curative therapy," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-13, March.

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