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The Circulating CTRP13 in Type 2 Diabetes and Non-Alcoholic Fatty Liver Patients

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  • Mehrnoosh Shanaki
  • Reza Fadaei
  • Nariman Moradi
  • Solaleh Emamgholipour
  • Hossein Poustchi

Abstract

Numerous studies have shown that C1q/TNF-related proteins (CTRPs) are involved in the pathophysiology of metabolic disorders, such as Non-alcoholic fatty liver disease (NAFLD) and Type 2 Diabetes (T2DM). There is a little information concerning CTRP13 in the context of NAFLD and T2DM. We evaluated the plasma levels of CTRP13 in healthy control and patients with NAFLD, T2DM and NAFLD+T2DM, and also correlations between CTRP13 plasma levels and clinical and subclinical features. Circulating CTRP13 was examined in 88 male (20 healthy control, 22 T2DM patients, 22 NAFLD patients and 22 NAFLD+T2DM patients). CTRP13 and adiponectin plasma levels were measured by ELISA method. CTRP13 serum levels were higher in the control group than the other groups (all p

Suggested Citation

  • Mehrnoosh Shanaki & Reza Fadaei & Nariman Moradi & Solaleh Emamgholipour & Hossein Poustchi, 2016. "The Circulating CTRP13 in Type 2 Diabetes and Non-Alcoholic Fatty Liver Patients," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0168082
    DOI: 10.1371/journal.pone.0168082
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    1. Bo Ban & Bo Bai & Manman Zhang & Jiamiao Hu & Manjunath Ramanjaneya & Bee K Tan & Jing Chen, 2014. "Low Serum Cartonectin/CTRP3 Concentrations in Newly Diagnosed Type 2 Diabetes Mellitus: In Vivo Regulation of Cartonectin by Glucose," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-5, November.
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