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High Prevalence of Faecal Carriage of ESBL-Producing Enterobacteriaceae among Children in Dar es Salaam, Tanzania

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  • Marit G Tellevik
  • Bjørn Blomberg
  • Øyvind Kommedal
  • Samuel Y Maselle
  • Nina Langeland
  • Sabrina J Moyo

Abstract

Background: Faecal carriage of ESBL-producing bacteria is a potential risk for transmission and infection. Little is known about faecal carriage of antibiotic resistance in Tanzania. This study aimed to investigate the prevalence of faecal carriage of ESBL-producing Enterobacteriaceae and to identify risk factors for carriage among young children in Tanzania. Methodology/Principal Findings: From August 2010 to July 2011, children below 2 years of age were recruited in Dar es Salaam, including healthy community children (n = 250) and children hospitalized due to diarrhoea (n = 250) or other diseases (n = 103). ChromID ESBL agar and ChromID CARBA SMART agar were used for screening. Antimicrobial susceptibility testing was performed by the disk diffusion method. ESBL genotypes were identified by Real-Time PCR and sequencing. Conclusions/Significance: We report a high rate of faecal carriage of ESBL-producing Enterobacteriaceae among children below 2 years of age in Tanzania, particularly those with HIV-infection. Resistance to a majority of the available antimicrobials commonly used for children in Tanzania leaves few treatment options for infections when caused by these bacteria.

Suggested Citation

  • Marit G Tellevik & Bjørn Blomberg & Øyvind Kommedal & Samuel Y Maselle & Nina Langeland & Sabrina J Moyo, 2016. "High Prevalence of Faecal Carriage of ESBL-Producing Enterobacteriaceae among Children in Dar es Salaam, Tanzania," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0168024
    DOI: 10.1371/journal.pone.0168024
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