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Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin

Author

Listed:
  • Tessel E Galesloot
  • Niek Verweij
  • Michela Traglia
  • Caterina Barbieri
  • Freerk van Dijk
  • Anneke J Geurts-Moespot
  • Domenico Girelli
  • Lambertus A L M Kiemeney
  • Fred C G J Sweep
  • Morris A Swertz
  • Peter van der Meer
  • Clara Camaschella
  • Daniela Toniolo
  • Sita H Vermeulen
  • Pim van der Harst
  • Dorine W Swinkels

Abstract

Serum hepcidin concentration is regulated by iron status, inflammation, erythropoiesis and numerous other factors, but underlying processes are incompletely understood. We studied the association of common and rare single nucleotide variants (SNVs) with serum hepcidin in one Italian study and two large Dutch population-based studies. We genotyped common SNVs with genome-wide association study (GWAS) arrays and subsequently performed imputation using the 1000 Genomes reference panel. Cohort-specific GWAS were performed for log-transformed serum hepcidin, adjusted for age and gender, and results were combined in a fixed-effects meta-analysis (total N 6,096). Six top SNVs (p

Suggested Citation

  • Tessel E Galesloot & Niek Verweij & Michela Traglia & Caterina Barbieri & Freerk van Dijk & Anneke J Geurts-Moespot & Domenico Girelli & Lambertus A L M Kiemeney & Fred C G J Sweep & Morris A Swertz &, 2016. "Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0166628
    DOI: 10.1371/journal.pone.0166628
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    1. Tune H. Pers & Juha M. Karjalainen & Yingleong Chan & Harm-Jan Westra & Andrew R. Wood & Jian Yang & Julian C. Lui & Sailaja Vedantam & Stefan Gustafsson & Tonu Esko & Tim Frayling & Elizabeth K. Spel, 2015. "Biological interpretation of genome-wide association studies using predicted gene functions," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
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