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Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis

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  • Chenyi Ye
  • Mingyuan Xu
  • Shengdong Wang
  • Shuai Jiang
  • Xi Chen
  • Xiaoyu Zhou
  • Rongxin He

Abstract

Background: There is conflicting evidence regarding the association between decreased bone mineral density (BMD) and atherosclerosis. To this end, we performed a systematic review and meta-analysis to clarify the association. Methods: To identify relevant studies, PubMed, Embase, and the Cochrane Library were systematically searched up to November 2015. All observational and comparative studies directly investigating the relationship between decreased BMD and clinical consequences of atherosclerotic vascular abnormalities, including carotid artery calcification (CAC), cardiovascular disease (CAD), and coronary artery disease (CAD) were obtained, without limitation of language or publication year. Results: A total of 25 studies involving 10,299 patients were included. The incidence of atherosclerotic vascular abnormalities was significantly increased in low BMD patients, compared to patients with normal BMD (OR, 1.81, 95% CI [1.01, 2.19], p

Suggested Citation

  • Chenyi Ye & Mingyuan Xu & Shengdong Wang & Shuai Jiang & Xi Chen & Xiaoyu Zhou & Rongxin He, 2016. "Decreased Bone Mineral Density Is an Independent Predictor for the Development of Atherosclerosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-18, May.
    • Handle: RePEc:plo:pone00:0154740
    DOI: 10.1371/journal.pone.0154740
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