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A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity

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  • Andrew P Holmes
  • Ting Y Yu
  • Samantha Tull
  • Fahima Syeda
  • Stefan M Kuhlmann
  • Sian-Marie O’Brien
  • Pushpa Patel
  • Keith L Brain
  • Davor Pavlovic
  • Nigel A Brown
  • Larissa Fabritz
  • Paulus Kirchhof

Abstract

Background: The left atrial posterior wall (LAPW) is potentially an important area for the development and maintenance of atrial fibrillation. We assessed whether there are regional electrical differences throughout the murine left atrial myocardium that could underlie regional differences in arrhythmia susceptibility. Methods: We used high-resolution optical mapping and sharp microelectrode recordings to quantify regional differences in electrical activation and repolarisation within the intact, superfused murine left atrium and quantified regional ion channel mRNA expression by Taqman Low Density Array. We also performed selected cellular electrophysiology experiments to validate regional differences in ion channel function. Results: Spontaneous ectopic activity was observed during sustained 1Hz pacing in 10/19 intact LA and this was abolished following resection of LAPW (0/19 resected LA, P

Suggested Citation

  • Andrew P Holmes & Ting Y Yu & Samantha Tull & Fahima Syeda & Stefan M Kuhlmann & Sian-Marie O’Brien & Pushpa Patel & Keith L Brain & Davor Pavlovic & Nigel A Brown & Larissa Fabritz & Paulus Kirchhof, 2016. "A Regional Reduction in Ito and IKACh in the Murine Posterior Left Atrial Myocardium Is Associated with Action Potential Prolongation and Increased Ectopic Activity," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-17, May.
    • Handle: RePEc:plo:pone00:0154077
    DOI: 10.1371/journal.pone.0154077
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    1. Christian Mosimann & Daniela Panáková & Andreas A. Werdich & Gabriel Musso & Alexa Burger & Katy L. Lawson & Logan A. Carr & Kathleen R. Nevis & M. Khaled Sabeh & Yi Zhou & Alan J. Davidson & Anthony , 2015. "Chamber identity programs drive early functional partitioning of the heart," Nature Communications, Nature, vol. 6(1), pages 1-10, November.
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