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High Pretreatment D-Dimer Levels Correlate with Adverse Clinical Features and Predict Poor Survival in Patients with Natural Killer/T-Cell Lymphoma

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Listed:
  • Xi-wen Bi
  • Liang Wang
  • Wen-wen Zhang
  • Peng Sun
  • Shu-mei Yan
  • Pan-pan Liu
  • Zhi-ming Li
  • Wen-qi Jiang

Abstract

Pretreatment plasma D-dimer levels have been reported to predict survival in several types of malignancies. The aim of this study was to evaluate the prognostic value of D-dimer levels in patients with newly diagnosed natural killer/T-cell lymphoma (NKTCL). The cut-off value of D-dimer to predict survival was set as 1.2 μg/mL based on the receiver operating curve analysis. Patients with a D-dimer level ≥ 1.2 μg/mL had significantly more adverse clinical features, including poor performance status, advanced stage diseases, B symptoms, elevated serum lactic dehydrogenase levels, involvement of regional lymph nodes, more extranodal diseases, and higher International Prognostic Index and natural killer/T-cell lymphoma prognostic index scores. A D-dimer level ≥ 1.2 μg/mL was significantly associated with inferior 3-year overall survival (OS, 13.0 vs. 68.5%, P

Suggested Citation

  • Xi-wen Bi & Liang Wang & Wen-wen Zhang & Peng Sun & Shu-mei Yan & Pan-pan Liu & Zhi-ming Li & Wen-qi Jiang, 2016. "High Pretreatment D-Dimer Levels Correlate with Adverse Clinical Features and Predict Poor Survival in Patients with Natural Killer/T-Cell Lymphoma," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0152842
    DOI: 10.1371/journal.pone.0152842
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