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Age-Related Changes of Intraocular Pressure in Elderly People in Southern China: Lingtou Eye Cohort Study

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  • Xiaotong Han
  • Yong Niu
  • Xinxing Guo
  • Yin Hu
  • William Yan
  • Mingguang He

Abstract

Purpose: To study age-related changes of intraocular pressure (IOP) and assess the cohort effect in both cross-sectional and longitudinal settings among elderly Chinese adults. Methods: Participants were enrolled from the Lingtou Eye Cohort Study with Chinese government officials aged 40 years and older at baseline and received physical check-up and ocular examinations from 2010 to 2012. IOP was measured using a non-contact tonometer according to standardized protocols, as well as systolic blood pressure (SBP), diastolic blood pressure (DBP) and body mass index (BMI). Participants who had attended IOP measurements in both 2010 and 2012 were included in this study. Cross-sectional association of IOP with age was assessed using multivariate liner regression analyses and based on the data of 2010. Longitudinal changes in IOP were assessed by paired t-test. Results: A total of 3372 subjects were enrolled in the current analysis (2010 mean [SD] age, 61.9 [7.1] years; 60.2% men). The mean IOP in 2010 was 15.4±2.3 mmHg for women and 15.2±2.3 mmHg for men with an intersex difference (P = 0.029). Cross-sectional analysis showed that IOP was negatively associated with age (P = 0.003, β = -0.033 for women and P

Suggested Citation

  • Xiaotong Han & Yong Niu & Xinxing Guo & Yin Hu & William Yan & Mingguang He, 2016. "Age-Related Changes of Intraocular Pressure in Elderly People in Southern China: Lingtou Eye Cohort Study," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0151766
    DOI: 10.1371/journal.pone.0151766
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