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Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men

Author

Listed:
  • Haakon E Meyer
  • Nathalie C Støer
  • Sven O Samuelsen
  • Rune Blomhoff
  • Trude E Robsahm
  • Magritt Brustad
  • Edward L Giovannucci
  • Tone Bjørge

Abstract

Objective: A number of observational studies have shown an inverse association between circulating 25-hydroxyvitamin D and total mortality, but a reverse J-shaped association has also been reported. In a large nested case-control study, serum-25-hydroxyvitamin D (s-25(OH)D) was positively associated with incident prostate cancer. Based on the same study population, the primary aim of the present study was to investigate the association between s-25(OH)D and total mortality. Methods: Men participating in population based health screenings during 1981–1991 and enrolled in a nested case-control study were followed throughout 2007 with respect to all-cause and cause-specific mortality. Hazard ratios (HR) with 95% confidence intervals (CI) were calculated using Cox proportional hazards regression. Results: In men with prostate cancer (n = 2282), there was a significant inverse association between s-25(OH)D and total mortality after controlling for potential confounders (HR = 1.25 (95% CI 1.05–1.50), s-25(OH)D

Suggested Citation

  • Haakon E Meyer & Nathalie C Støer & Sven O Samuelsen & Rune Blomhoff & Trude E Robsahm & Magritt Brustad & Edward L Giovannucci & Tone Bjørge, 2016. "Long Term Association between Serum 25-Hydroxyvitamin D and Mortality in a Cohort of 4379 Men," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0151441
    DOI: 10.1371/journal.pone.0151441
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