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Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process

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  • Cecilia Forcato
  • Luz Bavassi
  • Gabriela De Pino
  • Rodrigo Sebastián Fernández
  • Mirta Fabiana Villarreal
  • María Eugenia Pedreira

Abstract

Consolidated memories return to a labile state after the presentation of cues (reminders) associated with acquisition, followed by a period of stabilization (reconsolidation). However not all cues are equally effective in initiating the process, unpredictable cues triggered it, predictable cues do not. We hypothesize that the different effects observed by the different reminder types on memory labilization-reconsolidation depend on a differential neural involvement during reminder presentation. To test it, we developed a declarative task and compared the efficacy of three reminder types in triggering the process in humans (Experiment 1). Finally, we compared the brain activation patterns between the different conditions using functional magnetic resonance imaging (fMRI) (Experiment 2). We confirmed that the unpredictable reminder is the most effective in initiating the labilization-reconsolidation process. Furthermore, only under this condition there was differential left hippocampal activation during its presentation. We suggest that the left hippocampus is detecting the incongruence between actual and past events and allows the memory to be updated.

Suggested Citation

  • Cecilia Forcato & Luz Bavassi & Gabriela De Pino & Rodrigo Sebastián Fernández & Mirta Fabiana Villarreal & María Eugenia Pedreira, 2016. "Differential Left Hippocampal Activation during Retrieval with Different Types of Reminders: An fMRI Study of the Reconsolidation Process," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0151381
    DOI: 10.1371/journal.pone.0151381
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    References listed on IDEAS

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    1. Karim Nader & Glenn E. Schafe & Joseph E. Le Doux, 2000. "Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval," Nature, Nature, vol. 406(6797), pages 722-726, August.
    2. Cecilia Forcato & Rodrigo S Fernandez & María E Pedreira, 2013. "The Role and Dynamic of Strengthening in the Reconsolidation Process in a Human Declarative Memory: What Decides the Fate of Recent and Older Memories?," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-12, April.
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