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Oral Contraceptives and Multiple Sclerosis/Clinically Isolated Syndrome Susceptibility

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  • Kerstin Hellwig
  • Lie H Chen
  • Frank Z Stancyzk
  • Annette M Langer-Gould

Abstract

Background: The incidence of multiple sclerosis (MS) is rising in women. Objective: To determine whether the use of combined oral contraceptives (COCs) are associated with MS risk and whether this varies by progestin content. Methods: We conducted a nested case-control study of females ages 14–48 years with incident MS or clinically isolated syndrome (CIS) 2008–2011 from the membership of Kaiser Permanente Southern California. Controls were matched on age, race/ethnicity and membership characteristics. COC use up to ten years prior to symptom onset was obtained from the complete electronic health record. Results: We identified 400 women with incident MS/CIS and 3904 matched controls. Forty- percent of cases and 32% of controls had used COCs prior to symptom onset. The use of COCs was associated with a slightly increased risk of MS/CIS (adjusted OR = 1.52, 95%CI = 1.21–1.91; p

Suggested Citation

  • Kerstin Hellwig & Lie H Chen & Frank Z Stancyzk & Annette M Langer-Gould, 2016. "Oral Contraceptives and Multiple Sclerosis/Clinically Isolated Syndrome Susceptibility," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-12, March.
    • Handle: RePEc:plo:pone00:0149094
    DOI: 10.1371/journal.pone.0149094
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