IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0145399.html
   My bibliography  Save this article

Interactions among Candidate Genes Selected by Meta-Analyses Resulting in Higher Risk of Ischemic Stroke in a Chinese Population

Author

Listed:
  • Man Luo
  • Jiaoxing Li
  • Xunsha Sun
  • Rong Lai
  • Yufang Wang
  • Xiaowei Xu
  • Wenli Sheng

Abstract

Ischemic stroke (IS) is a multifactorial disorder caused by both genetic and environmental factors. The combined effects of multiple susceptibility genes might result in a higher risk for IS than a single gene. Therefore, we investigated whether interactions among multiple susceptibility genes were associated with an increased risk of IS by evaluating gene polymorphisms identified in previous meta-analyses, including methylenetetrahydrofolate reductase (MTHFR) C677T, beta fibrinogen (FGB, β-FG) A455G and T148C, apolipoprotein E (APOE) ε2–4, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), and endothelial nitric oxide synthase (eNOS) G894T. In order to examine these interactions, 712 patients with IS and 774 controls in a Chinese Han population were genotyped using the SNaPshot method, and multifactor dimensionality reduction analysis was used to detect potential interactions among the candidate genes. The results of this study found that ACE I/D and β-FG T148C were significant synergistic contributors to IS. In particular, the ACE DD + β-FG 148CC, ACE DD + β-FG 148CT, and ACE ID + β-FG 148CC genotype combinations resulted in higher risk of IS. After adjusting for potential confounding IS risk factors (age, gender, family history of IS, hypertension history and history of diabetes mellitus) using a logistic analysis, a significant correlation between the genotype combinations and IS patients persisted (overall stroke: adjusted odds ratio [OR] = 1.57, 95% confidence interval [CI]: 1.22–2.02, P

Suggested Citation

  • Man Luo & Jiaoxing Li & Xunsha Sun & Rong Lai & Yufang Wang & Xiaowei Xu & Wenli Sheng, 2015. "Interactions among Candidate Genes Selected by Meta-Analyses Resulting in Higher Risk of Ischemic Stroke in a Chinese Population," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-10, December.
    • Handle: RePEc:plo:pone00:0145399
    DOI: 10.1371/journal.pone.0145399
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145399
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145399&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0145399?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Landin Boring & Jennifa Gosling & Michael Cleary & Israel F. Charo, 1998. "Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis," Nature, Nature, vol. 394(6696), pages 894-897, August.
    2. Meiyun Wang & Xiubo Jiang & Wenlong Wu & Dongfeng Zhang, 2013. "Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-9, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lewis Taylor & Maximillian Hugo Brodermann & David McCaffary & Asif Jilani Iqbal & David R Greaves, 2016. "Netrin-1 Reduces Monocyte and Macrophage Chemotaxis towards the Complement Component C5a," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-22, August.
    2. Masanori Itakura & Kosuke Yamaguchi & Roma Kitazawa & Sei-Young Lim & Yusuke Anan & Jun Yoshitake & Takahiro Shibata & Lumi Negishi & Hikari Sugawa & Ryoji Nagai & Koji Uchida, 2022. "Histone functions as a cell-surface receptor for AGEs," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0145399. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.