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Albumin and Neutrophil Combined Prognostic Grade as a New Prognostic Factor in Non-Small Cell Lung Cancer: Results from a Large Consecutive Cohort

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  • Haifeng Sun
  • Pingping Hu
  • Hongchang Shen
  • Wei Dong
  • Tiehong Zhang
  • Qi Liu
  • Jiajun Du

Abstract

Objectives: It has been reported nutritional status and systemic inflammation were associated with the outcome of patients with malignancies. However, the prognostic value of combination of them was really scarce, especially in non-small cell lung cancer (NSCLC). In order to find a more simple and efficient predictor, we hypothesized that pretreatment albumin and neutrophil combined prognostic grade (ANPG) could offer an improved prognostic ability in NSCLC patients. Methods: We collected pretreatment albumin and neutrophil, clinicopathological, treatment and follow-up data of 1033 consecutive NSCLC patients treated between 2006 and 2011 in this retrospective study. The ANPG was calculated according to pretreatment albumin and neutrophil levels dichotomized by the optimal cut-off values, the quartile values and the clinical reference values. Kaplan-Meier (K-M) curves and Cox proportional regression were used for survival analyses. All the data was analyzed by SPSS 20.0. Results: According to optimal cut-off values and quartile values, significant differences were found in different pretreatment albumin, neutrophil levels and ANPG from the K-M curve (all p

Suggested Citation

  • Haifeng Sun & Pingping Hu & Hongchang Shen & Wei Dong & Tiehong Zhang & Qi Liu & Jiajun Du, 2015. "Albumin and Neutrophil Combined Prognostic Grade as a New Prognostic Factor in Non-Small Cell Lung Cancer: Results from a Large Consecutive Cohort," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0144663
    DOI: 10.1371/journal.pone.0144663
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    1. Konstantinos Rounis & Dimitrios Makrakis & Chara Papadaki & Alexia Monastirioti & Lambros Vamvakas & Konstantinos Kalbakis & Krystallia Gourlia & Iordanis Xanthopoulos & Ioannis Tsamardinos & Dimitrio, 2021. "Prediction of outcome in patients with non-small cell lung cancer treated with second line PD-1/PDL-1 inhibitors based on clinical parameters: Results from a prospective, single institution study," PLOS ONE, Public Library of Science, vol. 16(6), pages 1-18, June.

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