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ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection

Author

Listed:
  • Tarik Asselah
  • Stefan Zeuzem
  • Vicente Soriano
  • Jean-Pierre Bronowicki
  • Ansgar W Lohse
  • Beat Müllhaupt
  • Marcus Schuchmann
  • Marc Bourlière
  • Maria Buti
  • Stuart K Roberts
  • Edward J Gane
  • Jerry O Stern
  • Florian Voss
  • Patrick Baum
  • John-Paul Gallivan
  • Wulf O Böcher
  • Federico J Mensa

Abstract

Background & Aim: Whether inosine triphosphatase (ITPA) gene polymorphisms predict anemia during interferon-free therapy in chronic hepatitis C virus (HCV)-infected patients is unknown. We examined the relationship between two ITPA polymorphisms, anemia, and sustained virological response 12 weeks post-treatment (SVR12) in patients receiving the NS3/4A protease inhibitor faldaprevir, the non-nucleoside polymerase inhibitor deleobuvir, and ribavirin. Methods: HCV genotype 1-infected, treatment-naïve patients (N = 362) were randomized and treated in one of five treatment arms with faldaprevir and deleobuvir with or without ribavirin. Two ITPA polymorphisms (rs1127354 and rs6051702) were genotyped and defined as ITPA-deficient (rs1127354 AA or AC; rs6051702 CC or CA) or ITPA-non-deficient (rs1127354 CC; rs6051702 AA) according to their association with ITPA deficiency. Baseline and on-treatment variables associated with anemia and SVR12 were identified using logistic regression. Results: In the pooled ribavirin-containing arms, 10.1% (32/316) of patients experienced on-treatment hemoglobin

Suggested Citation

  • Tarik Asselah & Stefan Zeuzem & Vicente Soriano & Jean-Pierre Bronowicki & Ansgar W Lohse & Beat Müllhaupt & Marcus Schuchmann & Marc Bourlière & Maria Buti & Stuart K Roberts & Edward J Gane & Jerry , 2015. "ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0144004
    DOI: 10.1371/journal.pone.0144004
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    1. Jacques Fellay & Alexander J. Thompson & Dongliang Ge & Curtis E. Gumbs & Thomas J. Urban & Kevin V. Shianna & Latasha D. Little & Ping Qiu & Arthur H. Bertelsen & Mark Watson & Amelia Warner & Andrew, 2010. "ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C," Nature, Nature, vol. 464(7287), pages 405-408, March.
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