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The Value of MicroRNA-155 as a Prognostic Factor for Survival in Non-Small Cell Lung Cancer: A Meta-Analysis

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  • Fei Wang
  • Jianguo Zhou
  • Yu Zhang
  • Yi Wang
  • Long Cheng
  • Yuju Bai
  • Hu Ma

Abstract

Background: Recent studies have shown that miR-155 play a positive role in the development of carcinoma. This meta-analysis aimed to identify the role of miR-155 in the survival of non-small cell lung cancer patients. Methodology: Eligible studies were identified through database searches. Relevant data were extracted from each eligible study to assess the correlation between miR-155 expression and survival in lung carcinoma patients. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the patients’ outcomes in relation to miR-155 were calculated. A total of 6 studies were included for this meta-analysis. For overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), and cancer-specific survival (CSS), the combined HRs and 95% CIs were not statistically significant. Additionally, in Asian and America subgroups, greater expression levels of miR-155 were related to poor prognoses for lung cancer (HR 1.71 95% CI: 1.22–2.40, P = 0.002, HR 2.35 95% CI: 1.42–3.89 P = 0.001), while no significant relationship was present in a Europe subgroup (HR 0.75 95%CI: 0.27–2.10, P = 0.587). Conclusions: These results suggest that miR-155 expression is not significantly related to non-small cell lung cancer patients except in patients from Asian and America.

Suggested Citation

  • Fei Wang & Jianguo Zhou & Yu Zhang & Yi Wang & Long Cheng & Yuju Bai & Hu Ma, 2015. "The Value of MicroRNA-155 as a Prognostic Factor for Survival in Non-Small Cell Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0136889
    DOI: 10.1371/journal.pone.0136889
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