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Study of Five Pubertal Transition-Related Gene Polymorphisms as Risk Factors for Premature Coronary Artery Disease in a Chinese Han Population

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  • Bin Chen
  • Fangyi Xie
  • Chengchun Tang
  • Genshan Ma
  • Li Wei
  • Zhong Chen

Abstract

Background: Recently, single nucleotide polymorphisms (SNPs) (DLK-rs10144321, SIX6-rs1254337, MKRN3-rs12148769, LIN28B-rs7759938, and KCNK9-rs1469039) were found to be strongly associated with age at menarche. Recent studies also suggested that age at menarche is a heritable trait and is associated with risks for obesity, type 2 diabetes mellitus (T2DM), cardiovascular disease, and all-cause mortality. Since an association between these five SNPs and premature coronary artery disease (CAD) has never been reported, we investigated whether these SNPs are associated with premature CAD and its severity in a Chinese Han population. Methods: We enrolled 432 consecutive patients including 198 with premature CAD ( 0.05). Compared with controls, patients with premature CAD had a higher prevalence of T2DM and dyslipidemia, and the proportion of patients with T2DM rose significantly with an increase in the number of stenosed coronary vessels (all P

Suggested Citation

  • Bin Chen & Fangyi Xie & Chengchun Tang & Genshan Ma & Li Wei & Zhong Chen, 2015. "Study of Five Pubertal Transition-Related Gene Polymorphisms as Risk Factors for Premature Coronary Artery Disease in a Chinese Han Population," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0136496
    DOI: 10.1371/journal.pone.0136496
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