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Prostate Tumor Overexpressed 1 (PTOV1) Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Poor Survival Outcomes

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  • Qi Yang
  • Huanxin Lin
  • Shu Wu
  • Fangyong Lei
  • Xi Zhu
  • Libing Song
  • Minghuang Hong
  • Ling Guo

Abstract

Background: Prostate tumor overexpressed 1 (PTOV1) has been reported to contribute to increased cancer proliferation. However, the clinical significance of PTOV1 in the development and progression of nasopharyngeal carcinoma (NPC) is unclear. Our study aimed to investigate the expression pattern of PTOV1 in NPC and its correlation with clinicopathological features of patients. Methods: Western blotting and real-time PCR were conducted to examine PTOV1 expression levels in NPC cell lines and biopsy tissues compared with normal controls. Immunohistochemistry (IHC) was performed to analyze PTOV1 protein expression in paraffin-embedded tissues from 123 patients. Statistical analyses were applied to evaluate the clinical significance of PTOV1 expression. Results: PTOV1 mRNA and protein levels were upregulated in NPC cell lines and clinical samples. IHC analyses showed that PTOV1 was highly expressed in 68 (55.3%) of 123 NPC specimens. Statistical analysis revealed that PTOV1 expression was significantly correlated with clinical stage (P

Suggested Citation

  • Qi Yang & Huanxin Lin & Shu Wu & Fangyong Lei & Xi Zhu & Libing Song & Minghuang Hong & Ling Guo, 2015. "Prostate Tumor Overexpressed 1 (PTOV1) Is a Novel Prognostic Marker for Nasopharyngeal Carcinoma Progression and Poor Survival Outcomes," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-13, August.
    • Handle: RePEc:plo:pone00:0136448
    DOI: 10.1371/journal.pone.0136448
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