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Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia

Author

Listed:
  • Hideki Yoshida
  • Toshihiko Imamura
  • Akiko M Saito
  • Yoshihiro Takahashi
  • So-ichi Suenobu
  • Daiichiro Hasegawa
  • Takao Deguchi
  • Yoshiko Hashii
  • Hirohide Kawasaki
  • Mikiya Endo
  • Hiroki Hori
  • Nobuhiro Suzuki
  • Yoshiyuki Kosaka
  • Koji Kato
  • Keiko Yumura-Yagi
  • Junichi Hara
  • Megumi Oda
  • Atsushi Sato
  • Keizo Horibe
  • Japan Association of Childhood Leukemia Study (JACLS)

Abstract

Although L-asparaginase related hyperglycemia is well known adverse event, it is not studied whether the profile of this adverse event is affected by intensification of L-asparaginase administration. Here, we analyzed the profile of L-asparaginase related hyperglycemia in a 1,176 patients with pediatric acute lymphoblastic leukemia treated according to the Japan Association of Childhood Leukemia Study ALL-02 protocol using protracted L-asparaginase administration in maintenance phase. We determined that a total of 75 L-asparaginase related hyperglycemia events occurred in 69 patients. Although 17 events (17/1176, 1.4%) developed in induction phase, which was lower incidence than those (10–15%) in previous reports, 45 events developed during the maintenance phase with protracted L-asparaginase administration. Multivariate analysis showed that older age at onset (≥10 years) was a sole independent risk factor for L-asparaginase-related hyperglycemia (P

Suggested Citation

  • Hideki Yoshida & Toshihiko Imamura & Akiko M Saito & Yoshihiro Takahashi & So-ichi Suenobu & Daiichiro Hasegawa & Takao Deguchi & Yoshiko Hashii & Hirohide Kawasaki & Mikiya Endo & Hiroki Hori & Nobuh, 2015. "Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0136428
    DOI: 10.1371/journal.pone.0136428
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