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Increased Circulating Cathepsin K in Patients with Chronic Heart Failure

Author

Listed:
  • Guangxian Zhao
  • Yuzi Li
  • Lan Cui
  • Xiang Li
  • Zhenyi Jin
  • Xiongyi Han
  • Ennan Fang
  • Yihua Gao
  • Dongmei Zhou
  • Haiying Jiang
  • Xueying Jin
  • Guanghao Piao
  • Xiangshan Li
  • Guang Yang
  • Jiyong Jin
  • Enbo Zhu
  • Meina Piao
  • Limei Piao
  • Kuichang Yuan
  • Yanna Lei
  • Dazhi Ding
  • Chengzhi Jin
  • Yongshan Nan
  • Xianwu Cheng

Abstract

Cysteinyl cathepsin K (CatK) is one of the most potent mammalian collagenases involved in cardiovascular disease. Here, we investigated the clinical predictive value of serum CatK levels in patients with chronic heart failure (CHF). We examined 134 patients with CHF, measuring their serum CatK, troponin I, high-sensitive C-reactive protein, and pre-operative N-terminal pro-brain natriuretic peptide levels. The patients were divided into two groups: the 44 patients who showed a left ventricular (LV) ejection fraction (LVEF)

Suggested Citation

  • Guangxian Zhao & Yuzi Li & Lan Cui & Xiang Li & Zhenyi Jin & Xiongyi Han & Ennan Fang & Yihua Gao & Dongmei Zhou & Haiying Jiang & Xueying Jin & Guanghao Piao & Xiangshan Li & Guang Yang & Jiyong Jin , 2015. "Increased Circulating Cathepsin K in Patients with Chronic Heart Failure," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0136093
    DOI: 10.1371/journal.pone.0136093
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