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Tg in Adults as a Sensitive Biomarker of Iodine Status: A 5-Year Follow up Population Study in Different Levels of Iodine Intake Regions

Author

Listed:
  • Wei Chong
  • Xiaoguang Shi
  • Zhongyan Shan
  • Xiaochun Teng
  • Di Teng
  • Haixia Guan
  • Yushu Li
  • Ying Jin
  • Xiaohui Yu
  • Chenling Fan
  • Fan Yang
  • Hong Dai
  • Yang Yu
  • Jia Li
  • Yanyan Chen
  • Dong Zhao
  • Fengnan Hu
  • Jinyuan Mao
  • Xiaolan Gu
  • Rong Yang
  • Yajie Tong
  • Weibo Wang
  • Tianshu Gao
  • Chenyang Li
  • Weiping Teng

Abstract

This study was to evaluate the usefulness of serum thymoglobulin (Tg) in adults to assess iodine status through a 5-year cohort study which was conducted in three regions with different levels of iodine intake: mild deficiency, more than adequate, and excess, from 1999 to 2004 in China. A total of 3099 subjects over 14 years old with normal serum levels of Tg in 1999 were eligible, of whom 2448 were followed in 2004. Serum levels of thyroid hormones and thyroid autoantibodies as well as urine iodine were measured, and B-mode ultrasonography of the thyroid was performed. A general linear model was performed to determine the determinant factors of serum Tg. Among subjects with mildly deficient iodine intake, those with more than adequate intake, and those with excessive intake, the baseline levels of serum Tg were substantially different (7.5μg/L, 5.9μg/L, and 6.8μg/L respectively, P

Suggested Citation

  • Wei Chong & Xiaoguang Shi & Zhongyan Shan & Xiaochun Teng & Di Teng & Haixia Guan & Yushu Li & Ying Jin & Xiaohui Yu & Chenling Fan & Fan Yang & Hong Dai & Yang Yu & Jia Li & Yanyan Chen & Dong Zhao &, 2015. "Tg in Adults as a Sensitive Biomarker of Iodine Status: A 5-Year Follow up Population Study in Different Levels of Iodine Intake Regions," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0135553
    DOI: 10.1371/journal.pone.0135553
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