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Propensity Score Matching Analysis of Changes in Alpha-Fetoprotein Levels after Combined Radiotherapy and Transarterial Chemoembolization for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Author

Listed:
  • Yuri Jeong
  • Sang Min Yoon
  • Seungbong Han
  • Ju Hyun Shim
  • Kang Mo Kim
  • Young-Suk Lim
  • Han Chu Lee
  • So Yeon Kim
  • Jin-hong Park
  • Sang-wook Lee
  • Seung Do Ahn
  • Eun Kyung Choi
  • Jong Hoon Kim

Abstract

Background and Aim: To investigate the value of changes in alpha-fetoprotein (AFP) levels for the prediction of radiologic response and survival outcomes in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) who received combined treatment of 3-dimensional conformal radiotherapy (3D-CRT) and transarterial chemoembolization (TACE). Methods: A database of 154 HCC patients with PVTT and elevated AFP levels (>20 ng/mL) treated with 3D-CRT and TACE as an initial treatment between August 2002 and August 2008 was retrospectively reviewed. AFP levels were determined 1 month after radiotherapy, and AFP response was defined as an AFP level reduction of >20% from the initial level. Radiologic response, overall survival (OS), and progression-free survival (PFS) rates were compared between AFP responders and non-responders. Propensity-score based matching analysis was performed to minimize the effect of potential confounding bias. Results: The median follow-up period was 11.1 months (range, 3.1–82.7 months). In the propensity-score matching cohort (92 pairs), a best radiologic response of CR or PR occurred in more AFP responders than AFP non-responders (41.3% vs. 10.9%, p

Suggested Citation

  • Yuri Jeong & Sang Min Yoon & Seungbong Han & Ju Hyun Shim & Kang Mo Kim & Young-Suk Lim & Han Chu Lee & So Yeon Kim & Jin-hong Park & Sang-wook Lee & Seung Do Ahn & Eun Kyung Choi & Jong Hoon Kim, 2015. "Propensity Score Matching Analysis of Changes in Alpha-Fetoprotein Levels after Combined Radiotherapy and Transarterial Chemoembolization for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0135298
    DOI: 10.1371/journal.pone.0135298
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