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Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population

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  • Bridget Ann Knight
  • Beverley M Shields
  • Adam Brook
  • Anita Hill
  • Dattatray S Bhat
  • Andrew T Hattersley
  • Chittaranjan S Yajnik

Abstract

Objective: Vitamin B12 and folate are critical micronutrients needed to support the increased metabolic demands of pregnancy. Recent studies from India have suggested that low vitamin B12 and folate concentrations in pregnancy are associated with increased obesity; however differences in diet, antenatal vitamin supplementation, and socioeconomic status may limit the generalisability of these findings. We aimed to explore the cross-sectional relationship of circulating serum vitamin B12 and folate at 28 weeks’ gestation with maternal adiposity and related biochemical markers in a white non diabetic UK obstetric cohort. Methods: Anthropometry and biochemistry data was available on 995 women recruited at 28 weeks gestation to the Exeter Family Study of Childhood Health. Associations between B12 and folate with maternal BMI and other obesity-related biochemical factors (HOMA-R, fasting glucose, triglycerides, HDL and AST) were explored using regression analysis, adjusting for potential confounders (socioeconomic status, vegetarian diet, vitamin supplementation, parity, haemodilution (haematocrit)). Results: Higher 28 week BMI was associated with lower circulating vitamin B12 (r = -0.25; P

Suggested Citation

  • Bridget Ann Knight & Beverley M Shields & Adam Brook & Anita Hill & Dattatray S Bhat & Andrew T Hattersley & Chittaranjan S Yajnik, 2015. "Lower Circulating B12 Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0135268
    DOI: 10.1371/journal.pone.0135268
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    Cited by:

    1. Sara Al-Musharaf & Philip G. McTernan & Syed Danish Hussain & Khalid Abdullah Aleisa & Abdullah M. Alnaami & Kaiser Wani & Ponnusamy Saravanan & Nasser Al-Daghri, 2020. "Prevalence and Indicators of Vitamin B12 Insufficiency among Young Women of Childbearing Age," IJERPH, MDPI, vol. 18(1), pages 1-13, December.

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