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The Oral Tolerance as a Complex Network Phenomenon

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Listed:
  • Pedro Jeferson Miranda
  • Murilo Delgobo
  • Giovani Favero Marino
  • Kátia Sabrina Paludo
  • Murilo da Silva Baptista
  • Sandro Ely de Souza Pinto

Abstract

The phenomenon of oral tolerance refers to a local and systemic state of tolerance induced in the gut after its exposure to innocuous antigens. Recent findings have shown the interrelationship between cellular and molecular components of oral tolerance, but its representation through a network of interactions has not been investigated. Our work aims at identifying the causal relationship of each element in an oral tolerance network, and also to propose a phenomenological model that’s capable of predicting the stochastic behavior of this network when under manipulation. We compared the changes of a “healthy” network caused by “knock-outs” (KOs) in two approaches: an analytical approach by the Perron Frobenius theory; and a computational approach, which we describe within this work in order to find numerical results for the model. Both approaches have shown the most relevant immunological components for this phenomena, that happens to corroborate the empirical results from animal models. Besides explain in a intelligible fashion how the components interacts in a complex manner, we also managed to describe and quantify the importance of KOs that hasn’t been empirically tested.

Suggested Citation

  • Pedro Jeferson Miranda & Murilo Delgobo & Giovani Favero Marino & Kátia Sabrina Paludo & Murilo da Silva Baptista & Sandro Ely de Souza Pinto, 2015. "The Oral Tolerance as a Complex Network Phenomenon," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-17, June.
    • Handle: RePEc:plo:pone00:0130762
    DOI: 10.1371/journal.pone.0130762
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    References listed on IDEAS

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    1. Anna Cebula & Michal Seweryn & Grzegorz A. Rempala & Simarjot Singh Pabla & Richard A. McIndoe & Timothy L. Denning & Lynn Bry & Piotr Kraj & Pawel Kisielow & Leszek Ignatowicz, 2013. "Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota," Nature, Nature, vol. 497(7448), pages 258-262, May.
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