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Clinicopathological Characteristics of Gynecological Cancer Associated with Hypoxia-Inducible Factor 1α Expression: A Meta-Analysis Including 6,612 Subjects

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  • Yue Jin
  • Haolu Wang
  • Xiaowei Ma
  • Xiaowen Liang
  • Xin Liu
  • Yu Wang

Abstract

Background: Gynecological cancer is characterized by tumor hypoxia. However, the role of hypoxia-inducible factor 1α (HIF-1α) in gynecological cancer remains unclear. Method: Electronic databases including Cochrane Library, PUBMED, Web of Knowledge and clinical trial registries were searched from inception through October 2014 for published, case-control studies assessing the association between HIF-1α and the clinicopathological characteristics of gynecological cancer. We pooled results from 59 studies using fixed or random-effects models and present results as odds ratios (ORs) following the PRISMA guidelines. Results: Our meta-analysis, which included 6,612 women, demonstrated that the expression of HIF-1α was associated with the clinicopathological characteristics of gynecological cancer. The expression of HIF-1α in cancer or borderline tissue was significantly higher than that in normal tissue (cancer vs. normal: odds ratio (OR) =9.59, 95% confidence interval (CI): 5.97, 15.39, p

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  • Yue Jin & Haolu Wang & Xiaowei Ma & Xiaowen Liang & Xin Liu & Yu Wang, 2015. "Clinicopathological Characteristics of Gynecological Cancer Associated with Hypoxia-Inducible Factor 1α Expression: A Meta-Analysis Including 6,612 Subjects," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-23, May.
    • Handle: RePEc:plo:pone00:0127229
    DOI: 10.1371/journal.pone.0127229
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