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Environmental Factors Related to Multiple Sclerosis in Indian Population

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  • Chaithra Malli
  • Lekha Pandit
  • Anita D’Cunha
  • Sharik Mustafa

Abstract

Background: Multiple sclerosis (MS) is less prevalent among Indians when compared to white populations. Genetic susceptibility remaining the same it is possible that environmental associations may have a role in determining disease prevalence. Aims: To determine whether childhood infections, vaccination status, past infection with Helicobacter pylori (H.pylori), diet, socioeconomic and educational status were associated with MS. Material and Methods: 139 patients and 278 matched control subjects were selected. A validated environmental exposure questionnaire was administered. Estimation of serum H.pylori IgG antibody was done by ELISA. Patients and controls were genotyped for HLA-DRB1*15:01. Results: In our cohort a significant association was seen with measles (p

Suggested Citation

  • Chaithra Malli & Lekha Pandit & Anita D’Cunha & Sharik Mustafa, 2015. "Environmental Factors Related to Multiple Sclerosis in Indian Population," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-7, April.
    • Handle: RePEc:plo:pone00:0124064
    DOI: 10.1371/journal.pone.0124064
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