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Graft-Versus-Host Disease Prophylaxis after Transplantation: A Network Meta-Analysis

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  • Panayiotis D Ziakas
  • Fainareti N Zervou
  • Ioannis M Zacharioudakis
  • Eleftherios Mylonakis

Abstract

Background: Graft-versus-host Disease (GvHD) prophylaxis after allogeneic hematopoietic stem-cell transplantation (HSCT) is an ongoing effort but relative effects of different policies are not systematically explored. Methods: We systematically reviewed 30-year evidence on GvHD prophylaxis and quantified the relative effect of different policies using a network meta-analysis. We searched PubMed and the Cochrane Library for randomized studies on the topic. The primary outcome of interest was grade II-IV acute GvHD over 0 or I (with odds ratio OR

Suggested Citation

  • Panayiotis D Ziakas & Fainareti N Zervou & Ioannis M Zacharioudakis & Eleftherios Mylonakis, 2014. "Graft-Versus-Host Disease Prophylaxis after Transplantation: A Network Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-18, December.
    • Handle: RePEc:plo:pone00:0114735
    DOI: 10.1371/journal.pone.0114735
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