IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0114231.html
   My bibliography  Save this article

Pharmacological Interventions for Acceleration of the Onset Time of Rocuronium: A Meta-Analysis

Author

Listed:
  • Jing Dong
  • Lingqi Gao
  • Wenqing Lu
  • Zifeng Xu
  • Jijian Zheng

Abstract

Background: Rocuronium is an acceptable alternative when succinylcholine is contraindicated for facilitating the endotracheal intubation. However, the onset time of rocuronium for good intubation condition is still slower than that condition of succinylcholine. This study systematically investigated the most efficacious pharmacological interventions for accelerating the onset time of rocuronium. Methods: Medline, Embase, Cochrane Library databases, www.clinicaltrials.gov, and hand searching from the reference lists of identified papers were searched for randomized controlled trials comparing drug interventions with placebo or another drug to shorten the onset time of rocuronium. Statistical analyses were performed using RevMan5.2 and ADDIS 1.16.5 softwares. Mean differences (MDs) with their 95% confidence intervals (95% CIs) were used to analyze the effects of drug interventions on the onset time of rocuronium. Results: 43 randomized controlled trials with 2,465 patients were analyzed. The average onset time of rocuronium was 102.4±24.9 s. Priming with rocuronium [Mean difference (MD) −21.0 s, 95% confidence interval (95% CI) (−27.6 to −14.3 s)], pretreatment with ephedrine [−22.3 s (−29.1 to −15.5 s)], pretreatment with magnesium sulphate [−28.2 s (−50.9 to −5.6 s)] were all effective in reducing the onset time of rocuronium. Statistical testing of indirect comparisons showed that rocuronium priming, pretreatment with ephedrine, and pretreatment with magnesium sulphate had the similar efficacy. Conclusion: Rocuronium priming, pretreatment with ephedrine, and pretreatment with magnesium sulphate were all effective in accelerating the onset time of rocuronium, and furthermore their efficacies were similar. Considering the convenience and efficacy, priming with rocuronium is recommended for accelerating the onset time of rocuronium. However, more strict clinical trials are still needed to reach a more solid conclusion due to the large heterogeneities exist among different studies.

Suggested Citation

  • Jing Dong & Lingqi Gao & Wenqing Lu & Zifeng Xu & Jijian Zheng, 2014. "Pharmacological Interventions for Acceleration of the Onset Time of Rocuronium: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(12), pages 1-15, December.
  • Handle: RePEc:plo:pone00:0114231
    DOI: 10.1371/journal.pone.0114231
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114231
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114231&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0114231?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(4), pages 1-1.
    2. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(2), pages 1-1.
    3. Lu, Guobing & Ades, A.E., 2006. "Assessing Evidence Inconsistency in Mixed Treatment Comparisons," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 447-459, June.
    4. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(3), pages 1-1.
    5. Unknown, 2004. "Table of Contents," International Food and Agribusiness Management Review, International Food and Agribusiness Management Association, vol. 7(1), pages 1-1.
    6. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jian Zhang & Xuena Zhang & Hui Wang & Haibin Zhou & Tian Tian & Anshi Wu, 2017. "Dexmedetomidine as a neuraxial adjuvant for prevention of perioperative shivering: Meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-17, August.
    2. Elisa Sicuri & Azucena Bardají & Betuel Sigauque & Maria Maixenchs & Ariel Nhacolo & Delino Nhalungo & Eusebio Macete & Pedro L Alonso & Clara Menéndez, 2011. "Costs Associated with Low Birth Weight in a Rural Area of Southern Mozambique," PLOS ONE, Public Library of Science, vol. 6(12), pages 1-9, December.
    3. Shan Luo & Zehua Chen, 2014. "Sequential Lasso Cum EBIC for Feature Selection With Ultra-High Dimensional Feature Space," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(507), pages 1229-1240, September.
    4. Xuling Liu & Yang Yu & Shengmei Zhu, 2018. "Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): A meta-analysis of observational studies," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-22, April.
    5. Michelle Giles & Laura Graham & Jean Ball & Jennie King & Wendy Watts & Alison Harris & Christopher Oldmeadow & Rod Ling & Michelle Paul & Anthony O’Brien & Vicki Parker & John Wiggers & Maralyn Foure, 2020. "Implementation of a multifaceted nurse‐led intervention to reduce indwelling urinary catheter use in four Australian hospitals: A pre‐ and postintervention study," Journal of Clinical Nursing, John Wiley & Sons, vol. 29(5-6), pages 872-886, March.
    6. Qi-ling Yuan & Tuan-mao Guo & Liang Liu & Fu Sun & Yin-gang Zhang, 2015. "Traditional Chinese Medicine for Neck Pain and Low Back Pain: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-37, February.
    7. Cheemeng Tan & Robert Phillip Smith & Ming-Chi Tsai & Russell Schwartz & Lingchong You, 2014. "Phenotypic Signatures Arising from Unbalanced Bacterial Growth," PLOS Computational Biology, Public Library of Science, vol. 10(8), pages 1-10, August.
    8. Daisuke Nakajima & Hiromasa Kawakami & Takahiro Mihara & Hitoshi Sato & Takahisa Goto, 2020. "Effectiveness of intravenous lidocaine in preventing postoperative nausea and vomiting in pediatric patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-13, January.
    9. Anura Amarasinghe & Gerard D'Souza & Cheryl Brown & Hyungna Oh, 2006. "The Influence of Socioeconomic and Environmental Factors on Health and Obesity in Rural Appalachia," Working Papers Working Paper 2006-12, Regional Research Institute, West Virginia University.
    10. Michelle Tew & Philip Clarke & Karin Thursky & Kim Dalziel, 2019. "Incorporating Future Medical Costs: Impact on Cost-Effectiveness Analysis in Cancer Patients," PharmacoEconomics, Springer, vol. 37(7), pages 931-941, July.
    11. Meghan A Kirksey & Stephen C Haskins & Jennifer Cheng & Spencer S Liu, 2015. "Local Anesthetic Peripheral Nerve Block Adjuvants for Prolongation of Analgesia: A Systematic Qualitative Review," PLOS ONE, Public Library of Science, vol. 10(9), pages 1-23, September.
    12. Su Han & Xiaoli Zhang & Jingshan Wen & Yihong Li & Jing Shu & Hong Ling & Fengmin Zhang, 2012. "A Combination of the Kato-Katz Methods and ELISA to Improve the Diagnosis of Clonorchiasis in an Endemic Area, China," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-8, October.
    13. Frederick Schneider & Jan Martin & Alexander Hapfelmeier & Denis Jordan & Gerhard Schneider & Christian M Schulz, 2017. "The validity of linear and non-linear heart rate metrics as workload indicators of emergency physicians," PLOS ONE, Public Library of Science, vol. 12(11), pages 1-12, November.
    14. Jun’ichi Kotoku & Asuka Oyama & Kanako Kitazumi & Hiroshi Toki & Akihiro Haga & Ryohei Yamamoto & Maki Shinzawa & Miyae Yamakawa & Sakiko Fukui & Keiichi Yamamoto & Toshiki Moriyama, 2020. "Causal relations of health indices inferred statistically using the DirectLiNGAM algorithm from big data of Osaka prefecture health checkups," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-19, December.
    15. Juan Ni & Jiafu Wei & Yusheng Yao & Xiaoqin Jiang & Linli Luo & Dong Luo, 2015. "Effect of Dexmedetomidine on Preventing Postoperative Agitation in Children: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-13, May.
    16. Amarzaya Jadambaa & Nicholas Graves & Donna Cross & Rosana Pacella & Hannah J. Thomas & James G. Scott & Qinglu Cheng & David Brain, 2022. "Economic Evaluation of an Intervention Designed to Reduce Bullying in Australian Schools," Applied Health Economics and Health Policy, Springer, vol. 20(1), pages 79-89, January.
    17. Åsa Wallström & Gunilla Hollman Frisman, 2014. "Facilitating early recovery of bowel motility after colorectal surgery: a systematic review," Journal of Clinical Nursing, John Wiley & Sons, vol. 23(1-2), pages 24-44, January.
    18. Seo Hee Yoon & In Kyung Min & Jong Gyun Ahn, 2020. "Immunochromatography for the diagnosis of Mycoplasma pneumoniae infection: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-17, March.
    19. Hye Won Shin & Bum Jun Ju & Yoo Kyung Jang & Hae Seun You & Hyun Kang & Ji Yong Park, 2017. "Effect of tramadol as an adjuvant to local anesthetics for brachial plexus block: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-19, September.
    20. Jian Yu & Li Ren & Su Min & You Yang & Feng Lv, 2020. "Nebulized pharmacological agents for preventing postoperative sore throat: A systematic review and network meta-analysis," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-14, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0114231. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.