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Clinical Efficacy of Tumor Antigen-Pulsed DC Treatment for High-Grade Glioma Patients: Evidence from a Meta-Analysis

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  • Jun-Xia Cao
  • Xiao-Yan Zhang
  • Jin-Long Liu
  • Duo Li
  • Jun-Li Li
  • Yi-Shan Liu
  • Min Wang
  • Bei-Lei Xu
  • Hai-Bo Wang
  • Zheng-Xu Wang

Abstract

Background: The effectiveness of immunotherapy for high-grade glioma (HGG) patients remains controversial. To evaluate the therapeutic efficacy of dendritic cells (DCs) alone in the treatment of HGG, we performed a systematic review and meta-analysis in terms of patient survival with relevant published clinical studies. Materials and methods: A total of 409 patients, including historical cohorts, nonrandomized and randomized controls with HGG, were selected for the meta-analysis. Results: The treatment of HGG with DCs was associated with a significantly improved one-year survival (OS) (p 0.05), whereas CD56+ lymphocyte subset were significantly increased after DC treatment (p = 0.0001). Furthermore, the levels of IFN-γ in the peripheral blood of HGG patients, which reflect the immune function of the patients, were significantly increased after DC immunotherapy (p

Suggested Citation

  • Jun-Xia Cao & Xiao-Yan Zhang & Jin-Long Liu & Duo Li & Jun-Li Li & Yi-Shan Liu & Min Wang & Bei-Lei Xu & Hai-Bo Wang & Zheng-Xu Wang, 2014. "Clinical Efficacy of Tumor Antigen-Pulsed DC Treatment for High-Grade Glioma Patients: Evidence from a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0107173
    DOI: 10.1371/journal.pone.0107173
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