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Patients with Exon 19 Deletion Were Associated with Longer Progression-Free Survival Compared to Those with L858R Mutation after First-Line EGFR-TKIs for Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

Author

Listed:
  • Yaxiong Zhang
  • Jin Sheng
  • Shiyang Kang
  • Wenfeng Fang
  • Yue Yan
  • Zhihuang Hu
  • Shaodong Hong
  • Xuan Wu
  • Tao Qin
  • Wenhua Liang
  • Li Zhang

Abstract

Backgrounds: It has been extensively proved that the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is superior to that of cytotoxic chemotherapy in advanced non-small cell lung cancer (NSCLC) patients harboring sensitive EGFR mutations. However, the question of whether the efficacy of EGFR-TKIs differs between exon 19 deletion and exon 21 L858R mutation has not been yet statistically answered. Methods: Subgroup data on hazard ratio (HR) for progression-free survival (PFS) of correlative studies were extracted and synthesized based on random-effect model. Comparison of outcomes between specific mutations was estimated through indirect and direct methods, respectively. Results: A total of 13 studies of advanced NSCLC patients with either 19 or 21 exon alteration receiving first-line EGFR-TKIs were included. Based on the data from six clinical trials for indirect meta-analysis, the pooled HRTKI/chemotherapy for PFS were 0.28 (95% CI 0.20–0.38, P

Suggested Citation

  • Yaxiong Zhang & Jin Sheng & Shiyang Kang & Wenfeng Fang & Yue Yan & Zhihuang Hu & Shaodong Hong & Xuan Wu & Tao Qin & Wenhua Liang & Li Zhang, 2014. "Patients with Exon 19 Deletion Were Associated with Longer Progression-Free Survival Compared to Those with L858R Mutation after First-Line EGFR-TKIs for Advanced Non-Small Cell Lung Cancer: A Meta-An," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0107161
    DOI: 10.1371/journal.pone.0107161
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