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Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort

Author

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  • Raghavan Sampathkumar
  • Harold O Peters
  • Lillian Mendoza
  • Thomas Bielawny
  • Elizabeth Ngugi
  • Joshua Kimani
  • Charles Wachihi
  • Francis A Plummer
  • Ma Luo

Abstract

We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, -B, and -C were typed to 4-digit resolution using sequence-based typing method. HLA class I haplotype frequencies were estimated using PyPop 32-0.6.0. The influence of haplotypes on time to seroconversion and CD4+ T cell decline to

Suggested Citation

  • Raghavan Sampathkumar & Harold O Peters & Lillian Mendoza & Thomas Bielawny & Elizabeth Ngugi & Joshua Kimani & Charles Wachihi & Francis A Plummer & Ma Luo, 2014. "Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-12, July.
    • Handle: RePEc:plo:pone00:0101475
    DOI: 10.1371/journal.pone.0101475
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