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Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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  • Hai-Feng Shu
  • Tao Yang
  • Si-Xun Yu
  • Hai-Dong Huang
  • Ling-Li Jiang
  • Jian-Wen Gu
  • Yong-Qin Kuang

Abstract

Background: Although some trials assessed the effectiveness of aerobic exercise for Parkinson's disease (PD), the role of aerobic exercise in the management of PD remained controversial. Objective: The purpose of this systematic review is to evaluate the evidence about whether aerobic exercise is effective for PD. Methods: Seven electronic databases, up to December 2013, were searched to identify relevant studies. Two reviewers independently extracted data and assessed methodological quality based on PEDro scale. Standardised mean difference (SMD) and 95% confidence intervals (CI) of random-effects model were calculated. And heterogeneity was assessed based on the I2 statistic. Results: 18 randomized controlled trials (RCTs) with 901 patients were eligible. The aggregated results suggested that aerobic exercise should show superior effects in improving motor actions (SMD, −0.57; 95% CI −0.94 to −0.19; p = 0.003), balance (SMD, 2.02; 95% CI 0.45 to 3.59; p = 0.01), and gait (SMD, 0.33; 95% CI 0.17 to 0.49; p

Suggested Citation

  • Hai-Feng Shu & Tao Yang & Si-Xun Yu & Hai-Dong Huang & Ling-Li Jiang & Jian-Wen Gu & Yong-Qin Kuang, 2014. "Aerobic Exercise for Parkinson's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0100503
    DOI: 10.1371/journal.pone.0100503
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