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Intermediate-Type Vancomycin Resistance (VISA) in Genetically-Distinct Staphylococcus aureus Isolates Is Linked to Specific, Reversible Metabolic Alterations

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  • Elizabeth L Alexander
  • Susana Gardete
  • Haim Y Bar
  • Martin T Wells
  • Alexander Tomasz
  • Kyu Y Rhee

Abstract

Intermediate (VISA-type) vancomycin resistance in Staphylococcus aureus has been associated with a range of physiologic and genetic alterations. Previous work described the emergence of VISA-type resistance in two clonally-distinct series of isolates. In both series (the first belonging to MRSA clone ST8-USA300, and the second to ST5-USA100), resistance was conferred by a single mutation in yvqF (a negative regulator of the vraSR two-component system associated with vancomycin resistance). In the USA300 series, resistance was reversed by a secondary mutation in vraSR. In this study, we combined systems-level metabolomic profiling with statistical modeling techniques to discover specific, reversible metabolic alterations associated with the VISA phenotype.

Suggested Citation

  • Elizabeth L Alexander & Susana Gardete & Haim Y Bar & Martin T Wells & Alexander Tomasz & Kyu Y Rhee, 2014. "Intermediate-Type Vancomycin Resistance (VISA) in Genetically-Distinct Staphylococcus aureus Isolates Is Linked to Specific, Reversible Metabolic Alterations," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-9, May.
    • Handle: RePEc:plo:pone00:0097137
    DOI: 10.1371/journal.pone.0097137
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    1. Haim Y. Bar & James G. Booth & Martin T. Wells, 2014. "A Bivariate Model for Simultaneous Testing in Bioinformatics Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 109(506), pages 537-547, June.
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