Author
Listed:
- Liang Zheng
- Weifeng Tang
- Yijun Shi
- Suocheng Chen
- Xu Wang
- Liming Wang
- Aizhong Shao
- Guowen Ding
- Chao Liu
- Ruiping Liu
- Jun Yin
- Haiyong Gu
Abstract
Objective: Esophageal cancer was the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China in 2009. Genetic factors might play an important role in esophageal squamous cell carcinoma (ESCC) carcinogenesis. Designs and Methods: To evaluate the effect p21, p53, TP53BP1 and p73 single nucleotide polymorphisms (SNPs) on the risk of ESCC, we conducted a hospital based case–control study. A total of 629 ESCC cases and 686 controls were recruited. Their genotypes were determined using ligation detection reaction (LDR) method. Results: When the p21 rs3176352 GG homozygote genotype was used as the reference group, the CC genotype was associated with a significantly increased risk of ESCC. When the p73 rs1801173 CC homozygote genotype was used as the reference group, the CT genotype was associated with a significantly increased risk of ESCC. After Bonferroni correction, for p21 rs3176352 G>C, the pcorrect was still significant. For the other six SNPs, in all comparison models, no association between the polymorphisms and ESCC risk was observed. Conclusions: p21 rs3176352 G>C and p73 rs1801173 C>T SNPs are associated with increased risk of ESCC. To confirm the current findings, additional, larger studies and tissue-specific biological characterization are required.
Suggested Citation
Liang Zheng & Weifeng Tang & Yijun Shi & Suocheng Chen & Xu Wang & Liming Wang & Aizhong Shao & Guowen Ding & Chao Liu & Ruiping Liu & Jun Yin & Haiyong Gu, 2014.
"p21 rs3176352 G>C and p73 rs1801173 C>T Polymorphisms Are Associated with an Increased Risk of Esophageal Cancer in a Chinese Population,"
PLOS ONE, Public Library of Science, vol. 9(5), pages 1-7, May.
Handle:
RePEc:plo:pone00:0096958
DOI: 10.1371/journal.pone.0096958
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