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Serum YKL-40 Level Is Associated with the Chemotherapy Response and Prognosis of Patients with Small Cell Lung Cancer

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  • Chun-Hua Xu
  • Li -Ke Yu
  • Ke-Ke Hao

Abstract

This study was to explore the association between the serum YKL-40 level and the clinical characteristics, the response to chemotherapy and prognosis in small cell lung cancer (SCLC). Serum YKL-40 levels were detected and compared in 120 patients with SCLC pre- and post-chemotherapy, and in 40 healthy controls. Receiver operating characteristics (ROC) curves were adopted for diagnosis and calculation of area under ROC curve in SCLC. The Kaplan–Meier method, univariate and multivariate Cox regression analysis were used to analyze the correlation between pre-chemotherapy serum YKL-40 levels and progression-free survival (PFS) and overall survival (OS). The pre-chemotherapy serum YKL-40 levels were significantly higher than those of the controls (p

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  • Chun-Hua Xu & Li -Ke Yu & Ke-Ke Hao, 2014. "Serum YKL-40 Level Is Associated with the Chemotherapy Response and Prognosis of Patients with Small Cell Lung Cancer," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-8, May.
    • Handle: RePEc:plo:pone00:0096384
    DOI: 10.1371/journal.pone.0096384
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