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ComQXPA Quorum Sensing Systems May Not Be Unique to Bacillus subtilis: A Census in Prokaryotic Genomes

Author

Listed:
  • Iztok Dogsa
  • Kumari Sonal Choudhary
  • Ziva Marsetic
  • Sanjarbek Hudaiberdiev
  • Roberto Vera
  • Sándor Pongor
  • Ines Mandic-Mulec

Abstract

The comQXPA locus of Bacillus subtilis encodes a quorum sensing (QS) system typical of Gram positive bacteria. It encodes four proteins, the ComQ isoprenyl transferase, the ComX pre-peptide signal, the ComP histidine kinase, and the ComA response regulator. These are encoded by four adjacent genes all situated on the same chromosome strand. Here we present results of a comprehensive census of comQXPA-like gene arrangements in 2620 complete and 6970 draft prokaryotic genomes (sequenced by the end of 2013). After manually checking the data for false-positive and false-negative hits, we found 39 novel com-like predictions. The census data show that in addition to B. subtilis and close relatives, 20 comQXPA-like loci are predicted to occur outside the B. subtilis clade. These include some species of Clostridiales order, but none outside the phylum Firmicutes. Characteristic gene-overlap patterns were observed in comQXPA loci, which were different for the B. subtilis-like and non-B. subtilis-like clades. Pronounced sequence variability associated with the ComX peptide in B. subtilis clade is evident also in the non-B. subtilis clade suggesting grossly similar evolutionary constraints in the underlying quorum sensing systems.

Suggested Citation

  • Iztok Dogsa & Kumari Sonal Choudhary & Ziva Marsetic & Sanjarbek Hudaiberdiev & Roberto Vera & Sándor Pongor & Ines Mandic-Mulec, 2014. "ComQXPA Quorum Sensing Systems May Not Be Unique to Bacillus subtilis: A Census in Prokaryotic Genomes," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-8, May.
    • Handle: RePEc:plo:pone00:0096122
    DOI: 10.1371/journal.pone.0096122
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